Table IV.

Baseline risk factors of 686 patients for the presence of normal ALT/AST at discharge after hospitalization for COVID-19 infection (univariate and multivariate analysis).

	Univariate analysis				Multivariate analysis
Variables	Hazard ratio	P-value	95% Confidence interval Lower limit	95% Confidence interval Upper limit	Hazard ratio	P-value	95% Confidence interval Lower limit	95% Confidence interval Upper limit
Age, years	0.98	<0.001	0.97	0.99	0.98	<0.001	0.97	0.99
Sex, male	0.63	<0.001	0.51	0.79
Co-morbidities
Diabetes mellitus	0.61	0.001	0.45	0.82
Severe (class II) obesity (BMI ≥35)	1.15	0.45	0.79	1.69
Arterial hypertension	0.82	0.71	0.65	1.02
Gastrointestinal symptoms	1.26	0.14	0.92	1.73
AST (IU/l)	1.006	<0.001	1.004	1.008
ALT (IU/l)	1.004	<0.001	1.002	1.005	1.005	<0.001	1.003	1.007
ALP (IU/l)	1.00	0.66	0.99	1.002
γ-GT (IU/l)	1.001	0.12	0.99	1.002
Total bilirubin (mg/dl)	1.006	0.048	1.00	1.012
LDH (IU/l)	1.001	0.27	0.98	1.002
Albumin (g/dl)	1.002	0.16	0.99	1.004
CRP (mg/l)	1.00	0.85	0.99	1.001
INR	0.93	0.54	0.75	1.16
D-Dimers (mg/dl)	0.97	0.09	0.94	1.002
Fibrinogen (mg/dl)	1.00	0.98	0.99	1.001
Ferritin (ng/ml)	1.002	0.003	1.001	1.003
WBC (x109/l)	1.00	0.13	0.99	1.001
PLTs (x109/l)	1.00	0.68	0.99	1.001
HBsAg (+) or anti-HCV (+)	0.88	0.76	0.39	2.01
COVID-19 medication
Remdesivir	0.93	0.59	0.71	1.22
Dexamethasone	0.93	0.69	0.67	1.29
Tocilizumab	0.69	0.07	0.48	1.01

AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; γ-GT, γ-glutamyl transpeptidase; LDH, lactate dehydrogenase; INR, international normalized ratio; CRP, C-reactive protein; WBC, white blood count; PLTs, platelets.