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. 2022 Sep 19;48(5):197. doi: 10.3892/or.2022.8412

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — HMGB1 promotes the development of prostate cancer in vivo. (A-C) HMGB1 significantly increased the volume and weight of tumours in a LNCaP xenograft model. (D) The effect of HMGB1 on the level of PSA in mouse serum was examined by ELISA. (E) HMGB1 protein expression in mouse tumour tissues detected by IHC. (F) AR protein expression in mouse tumour tissues detected by IHC. *P<0.05. HMGB1, high-mobility group protein B1; PSA, prostate specific antigen; IHC, immunohistochemical; AR, androgen receptor; MOD, mean optical density.