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Cofilin-actin rods in neurons. Actin and cofilin bind to each other in a 1:1 ratio. Persistent cofilin-actin rods can occur under stress conditions, such as ATP depletion or oxidative stress brought upon by ROS. In neurons, these rods accumulate in the cytoplasm of processes (cytoplasmic rods) and in the nucleus (nuclear rods). Created with www.biorender.com.
