Table 2. Cytotoxic Activities (% of Inhibition) of the Extract, Natural Products, and Derivativesa.
| sample | U251 | PC-3 | K562 | HCT-15 | MCF-7 | SKLU-1 | COS7 |
|---|---|---|---|---|---|---|---|
| CH2Cl2/CH3OH 1:1 (leaves extract) | 52.31 | 43.6 | 74.63 | 34.5 | 62.45 | 58.35 | NP |
| (1) | 59.8 | 87.2 | 100 | 74.6 | 61.4 | 88.4 | 22.0 |
| euphol (2) | NA | NA | 26.9 | 2.18 | 36.62 | 4.9 | NA |
| lupeol (5) | 27.3 | 50.7 | 48.8 | 10.4 | 22.3 | 13.0 | NP |
| (6) | NA | NA | 33.1 | 15.6 | 1.3 | 10.9 | NA |
| (7) | NA | NA | 39.8 | 39.4 | 20.1 | 40.0 | NA |
| (8) | NA | NA | 95.0 | 12.2 | 1.5 | 31.3 | 17.2 |
| (10) | NA | NA | 57.8 | 4.3 | 4.3 | 21.6 | NA |
| (12) | NA | NA | 34.1 | 16.4 | NA | 4.6 | NA |
| etoposideb | 91.1c | 51.4d | 60.2d | 80.8d | 56.8d | 81.7d | NP |
NA: no activity; ND: not determined. Human tumor cell lines: U251 (glioblastoma), PC-3 (prostate), K562 (leukemia), HCT-15 (colon), MCF-7 (breast), and SKLU-1 (lung). COS7: noncancerous cell line of monkey kidney.
a
Concentrations: 50 μg/mL for the extract, 50 μM for pure compounds, DMSO vehicle.
b
Positive control.
c
Concentration at 10 μM.
d
Concentration at 31 μM.