TABLE 2.

Substitution rates of domain-encoding regions of lav homologs^a

Pair	Lav N terminus			Lav C terminus
	Ks	Ka	Ks/Ka	Ks	Ka	Ks/Ka
N. meningitidis serotype A vs N. meningitidis serotype B	0.167 (0.053)	0.156 (0.028)	1.07	0.093 (0.024)	0.021 (0.008)	4.36
N. meningitidis serotype A vs N. gonorrhoeae	0.096 (0.034)	0.120 (0.024)	0.80	0.201 (0.041)	0.065 (0.014)	3.08
N. meningitidis serotype A vs Int1	0.157 (0.052)	0.179 (0.030)	0.88	0.246 (0.042)	0.056 (0.011)	4.36
N. gonorrhoeae vs Int1	0.145 (0.044)	0.162 (0.030)	0.89	0.310 (0.046)	0.075 (0.014)	4.11
Biotype aegyptius vs N. meningitidis serotype A	—b	—	—	0.416 (0.065)	0.095 (0.0.016)	4.40
Biotype aegyptius vs N. gonorrhoeae	—	—	—	0.418 (0.063)	0.096 (0.016)	4.37
Biotype aegyptius vs Int1	—	—	—	0.448 (0.070)	0.100 (0.016)	4.50

^aPutative domain-encoding DNA sequences of the lav gene (Int1), orf2 homologs from Neisseria, and biotype aegyptius las were aligned using Clustal W (GCG), and pairwise substitutions were analyzed using DIVERGE (GCG). N-terminal domain-encoding regions of lav homologs are the first 283 codons after the GCAA repeats; C-terminal domain-encoding regions are the remaining 376 codons. Values are given as means, with standard deviations in parentheses. 

^b—, the biotype aegyptius las N-terminal domain-encoding region is too divergent to include in the alignment.