Table 1.

Univariate and multivariate analyses for relapse-free survival after hepatectomy

Variable		Univariate			Multivariate
		HR	95% CI	P-value †	HR	95% CI	P-value ‡
Genetic signatures
Tumor mutation burden
Hyper	146	1.41	0.97–2.10	0.079
Hypo	77
Multiple mutations
Present	178	1.97	1.19–3.53	0.012	1.72	1.01–3.17	0.045
Absent	45
Clinicopathological factors
Sex
Male	182	1.22	0.78–2.01	0.402
Female	41
Age, years
≥ 70	114	0.97	0.69–1.39	0.893
< 70	109
HBV or HCV
Negative	112	0.92	0.65–1.31	0.655
Positive	111
ICG-R15, %
≥ 20	13	1.30	0.64–2.36	0.424
< 20	210
AFP, ng/ml
≥ 200	48	1.40	0.91–2.09	0.106
< 200	171
PIVKA-II, mAU/ml
≥ 100	121	1.84	1.27–2.69	0.001	1.34	0.88–2.06	0.177
< 100	95
Tumor size, mm
≥ 30	132	1.68	1.16–2.46	0.006	1.23	0.84–1.96	0.257
< 30	91
Macrovascular invasion
Positive	15	2.43	1.23–4.32	0.004	1.72	0.86–3.10	0.119
Negative	208
Microvascular invasion
Positive	75	2.26	1.58–3.22	< 0.001	1.96	1.36–2.83	< 0.001
Negative	148
Liver damage
Liver cirrhosis	88	1.36	0.95–1.94	0.085
No cirrhosis	135

Significant values are in bold

HR Hazard ratio, CI Confidence interval, HBV Hepatitis B virus, HCV Hepatitis C virus, ICG Indocyanine green, RFS Relapse-free survival, AFP Alpha fetoprotein

^†Kaplan–Meier method. Significance was determined by the log-rank test

^‡Multivariate survival analysis was performed using Cox’s proportional hazard model