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. 2022 Oct 6;205:115279. doi: 10.1016/j.bcp.2022.115279

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© 2022 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — The life cycle of SARS-CoV-2 via RdRp. The RdRp is involved in virus genomic RNA (gRNA) and subgenomic mRNA (sg-mRNA) synthesis. Inhibitors targeting RdRp are promising candidates for antiviral therapy.