Fig. 3.

Cryo-EM structure of remdesivir bound to the RdRp complex of SARS-CoV-2(PDB ID:7BV2). (A) Chemical structures of remdesivir and remdesivir triphosphate. (B) Overall view of nsp12-nsp7-nsp8 in complex with template-primer RNA and remdesivir monophosphate (RDV-MP) and close-up view of the interactions between the SARS-CoV-2 RdRp active site and remdesivir. The potential polar contacts are shown as yellow dashed lines. The protein and RNA are shown in cartoons with the key residues involved in remdesivir interaction shown in lines and labeled in black and red, respectively. The RDV-MP is shown as a stick model.