Fig. 4.

Cryo-EM structure of favipiravir bound to the RdRp complex of SARS-CoV-2 (PDB ID:7CTT). (A) Chemical structures of favipiravir and favipiravir ribofuranosyl triphosphate (FPV-RTP). (B) Overall view of the FPV-RTP bound polymerase complex of SARS-CoV-2 and close-up views of recognition of FPV-RTP by SARS-CoV-2 polymerase complex. The potential polar contacts are shown as yellow dashed lines. The protein and RNA are shown in cartoons with the key residues involved in FPV-RTP interaction shown in lines and labeled in black and red, respectively. The FPV-RTP is shown as a stick model.