Fig. 5.

Cryo-EM structure of NHC bound to the RdRp complex of SARS-CoV-2. (A) Chemical structures of molnupiravir and NHC triphosphate. (B and C) Overview of RdRp-RNA structure with an NHC monophosphate in the RNA template strand and close-up views of the interactions between the SARS-CoV-2 RdRp active site and NHC base paired to A(B) (PDB ID:7OZU) and base paired to G(C) (PDB ID:7OZV). The potential polar contacts are shown as yellow dashed lines. The protein and RNA are shown in cartoons with the key residues involved in NHC interaction shown in lines and labeled in black and red, respectively. The NHC are shown as stick models.