Fig. 8.

Cryo-EM structure of suramin bound to the RdRp complex of SARS-CoV-2 (PDB ID:7D4F) (A) The chemical structure of suramin. (B) Overall view of the RdRp-suramin complex and close views of the interactions of the two suramin molecules with RdRp. Suramin no.1 directly blocks the binding of the RNA template strand, and suramin no.2 clashes with the RNA primer strand near the RdRp catalytic site. The potential polar contacts are shown as yellow dashed lines. The protein and RNA are shown in cartoons with the key residues involved in suramin interaction shown in lines and labeled. Suramin are shown as stick models.