Table 1.
Ki of Macrocyclic Compounds against BACE1 and BACE2
| ||||
|---|---|---|---|---|
| compd | R1 |
Ki against BACE1 (nM) |
Ki against BACE2 (nM) |
BACE1 selectivity |
| 1 | pentane | 21 ± 3 | 576 ± 38 | 28 |
| 2 | 2-propanol | 5 ± 3 | 1114 ± 40 | 214 |
| 3 | 2-pentanol | 7 ± 5 | 99 ± 29 | 15 |
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