Table 1. High fecundity genotypes in sheep showing affected gene, allele, line and breed, reported ovulation rate and percentage increase over wild type allele in heterozygous and homozygous carriers and proposed functional modifications in the proteins.
| Number of ovulations (% increase relative to controls) |
|||||
|---|---|---|---|---|---|
| Gene | Mutated allele | Name/Breed | Heterozygous | Homozygous | Ref. |
| BMPR1B | FecBB | Booroola | 2.8 (+85%) | 4.6-9.7 (+204% to 439%) |
Davis et al., 1982; Mulsant et al., 2001; Wilson et al., 2001; McNatty et al., 2017 |
| - | Mehraban | 1.3† (+25%) | NR | Abdoli et al., 2013 | |
| BMP15 | FecXI | Inverdale (Rommney) | 2.5-3.2 (+35% to 64%) | POF (primary stage) |
Braw-Tal et al., 1993; Shackell et al., 1993; Galloway et al., 2000; Davis et al., 2001a |
| FecXH | Hanna (Romney) | 2.6-3.2 (+46% to 72%) | POF (primary stage) |
Galloway et al., 2000; Davis et al., 2001a; Hanrahan et al., 2004 | |
| FecXB | Belclare (Belclare) | 3.3 (+70%) | POF | Hanrahan et al., 2004 | |
| FecXG | Galway (Belclare, Cambridge) |
2.7-3.1 (+37 to 42%) | POF | Hanrahan et al., 2004; McNatty et al., 2004 | |
| FecXL | Lac X-mutated (Lacaune) | 3.3-7.2 (+69% to +269%) | POF (primary stage) | Bodin et al., 2007; Drouilhet et al., 2009 | |
| FecXR | Raza Aragonesa | 2.0 (+46%) | POF | Martinez-Royo et al., 2008; Lahoz et al., 2011 | |
| FecXGr | Grivette | 2.9 (+16%)* | 4.6 (+81%) |
Demars et al., 2013 | |
| FecXO | Olkuska | 2.0 (+32%) | 3.3 (+142%) |
Demars et al., 2013 | |
| FecXBar | Tunisian Barbarine | 1.8 (+64%) | POF | Lassoued et al., 2017 | |
| GDF9 | FecGH | High Fertility (Belclare, Cambridge) |
4.3 (+88%) | POF | Hanrahan et al., 2004 |
| FecGT | Thoka (Icelandic) | +32% (lambing rate) | POF (primary/secondary) |
Nicol et al., 2009; Juengel et al., 2013 | |
| FecGE | Embrapa (Santa Ines) | 1.3 (+10%)* | 2.2 (+82%) |
McNatty et al., 2004; Silva et al., 2011 | |
| FecGV | Vacaria (Ile de France) | 2.4-2.5 (+94%) | POF (small antral follicles abnormal) |
Souza et al., 2014 | |
| FecGF | Finnsheep | 2.48 (+6%) | 2.98 (+28%) |
Vage et al., 2013; Mullen and Hanrahan, 2014 | |
| B4GALNT2† | FecLL | Lacaune | 3.1 (+114%) | 4.6 (+214%) |
Drouilhet et al., 2009 |
| Unknown | FecX2W | Woodlands (Coopworth) | 2.7 (+25%) | NR - fertile | Davis et al., 2001b |
| Unknown | FecW | Wishart (Romney) | +0.8-1.0 ovulations | NR-fertile | Davis et al., 2006 |
| Unknown | FecD | Davisdale (Border Leicester X Romney) |
+0.4-0.8 ova | NR - fertile | Juengel et al., 2011 |
*
Non-significant increases from wild-type controls. POF = Primary ovarian failure. NR = not reported.