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. 2022 Jun 14;42(10):1944–1960. doi: 10.1177/0271678X221107422

Figure 3.

Figure 3.

Variability of functional and morphological impairments in the ET1 model. (a) Distribution of spontaneous MUA in the ischemic focus averaged over all layers (MUA*) in 26 rats. The breakpoint of the two-exponential fit (green line) at the value of 7% was used to separate animals into groups with either high (>7%, n = 13) or low (<7%, n = 13) MUA* recovery. This value also corresponds to the median of the MUA* distribution (red line in the box plot above). (b) Examples of ischemic lesions in animals in the high and low recovery groups. Bottom, cumulative probability maps of the ischemic focus in the high (n = 10) and low (n = 12) recovery groups. Scale bar, 0.5 mm. (c) Correlation analysis between ischemic lesion area and MUA* in the ischemic focus (n = 22). Color-coded box plots show Q1-Q3 intervals, red lines show median, p-values for comparisons are color-coded according to the scale bar in panel d, bottom. The blue dashed line shows the linear approximation fit, the background color of the correlation coefficient R indicates the p-value. (d) Layer-specific analysis of the correlation between ischemic lesion length and MUA* in the focus. Circles indicate R and p-values for each layer. Squares indicate p-values for the difference between the high and low recovery groups. The bar for p-values is shown at the bottom.