Figure 2.

Relative age-related role of inflammatory components following stroke. Following stroke in the adult brain (blue line), infiltration of neutrophils, lymphocytes, microglia and monocytes contribute to neuronal injury and death. Many of these same factors contribute to neuronal injury in the juvenile brain (red line), though infiltration of T lymphocytes has not been established. Following neonatal stroke (orange line), resident microglial activation contributes to ischemic neuronal injury and death, but infiltration of neutrophils and monocytes are not involved in the pathogenic cascade. γδT-cells contribute to acute neuronal cell death following neonatal H-I, whereas CD4⁺ and CD8⁺ T-cells contribute to chronic inflammatory changes in the neonatal brain following ischemia.