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White matter lesion volume and hemodynamic physiology. There was no significant interaction between cerebral blood flow (CBF) and venous hyperintense signal (VHS) presence (VHS+) or absence (VHS−) on white matter lesion (WML) volume (a). However, there was a significant interaction between maximum oxygen extraction fraction (OEFmax) and VHS on WML volume, with lower OEFmax associated with higher WML volume in VHS+ participants and lower WML volume in VHS− participants (b).
