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. 2022 Jun 8;42(10):1920–1932. doi: 10.1177/0271678X221105683

Figure 2.

Figure 2.

GPC1 mediated effect of BACE1 on eNOS expression in human BMECs. a and b: Cells were treated with 30 nM BACE1siRNA or CtsiRNA for 48 hours (a) or 40 hours (b), the protein or mRNA levels of GPC1 were measured, respectively. (a) n = 12; (b) n = 4; *P < 0.05. PC-12 cell lysate was used as a GPC1 positive control. (c) Cells were transduced with Ad-BACE1 or Ad-Null (2.5 MOI, 2 days). n = 8, *P < 0.05. (d–f) Cells were treated with 30 nM GPC1siRNA or CtsiRNA for 2 days. mRNA expressions of GPC1 (d) and eNOS (e), as well as eNOS protein levels (f) were measured. D, n = 6; E, n = 7, F, n = 4; *P < 0.05.