Table 1.
Characteristics of male wild-type littermates and eBACE1−/− mice.
| Parameters | Cdh5-Cre−;BACE1flox/flox (WT) | Cdh5-Cre+;BACE1flox/flox (eBACE1−/−) |
|---|---|---|
| Tamoxifen (mg/kg BW/day) | 44 ± 8 (23) | 42 ± 7 (25) |
| BW (g) | 22 ± 2 (16) | 23 ± 2 (16) |
| SBP (mmHg) | 121 ± 4 (7) | 117 ± 8 (7) |
| MBP (mmHg) | 94 ± 3 (7) | 90 ± 6 (7) |
| DBP (mmHg) | 80 ± 4 (7) | 76 ± 5 (7) |
| Glucose (mg/dL) | 170 ± 24 (8) | 179 ± 17 (8) |
| Aβ1–40 (pg/mL) | 226 ± 45 (10) | 194 ± 29 (10)* |
| Aβ1–42 (pg/mL) | 57 ± 7 (12) | 50 ± 6 (12)** |
BW: body weight; SBP: systolic blood pressure; MBP: mean blood pressure; DBP: diastolic blood pressure; Aβ: amyloid-β; WT: wild-type. Data are means ± SD and the numbers of mice are indicated in the parentheses.
*P < 0.05 VS. WT littermates (Mann-Whitney U-test for non-parametric data).
**P < 0.05 vs. WT littermates (unpaired t-test).