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. 2022 Sep 8;7(17):e158737. doi: 10.1172/jci.insight.158737

Figure 5. Metabolite profiling in WT versus Sdh hKO mice under normoxic conditions.

Figure 5

(A) Average fold changes (log2FoldChange) of liver, heart, kidney, skin, and brain in 147 metabolites are ranked. Both Sdhd single-hKO (n = 3 mice) and Sdhb/c/d triple-hKO (n = 5 mice) tissues showed the highest increase in succinate, and the highest overlapping decreases in 3-hydroxybutyrate and l-cystine, relative to WT control mice (n = 2). A stringent outlier analysis by ROUT method (Q = 0.1%) detected only 4 outlier metabolites, marked by asterisks. (B) The ratios of succinate to fumarate and oxoglutarate were increased in Sdhb/c/d-hKO mice relative to WT. Data represent mean ± SEM.