Figure 4.

Prognostic factors of a complete relapse recovery and probability of a complete relapse recovery (as judged by the Investigator; full dataset). (A) The number of patients represents the number of patients with relapses with corresponding EDSS functional score assessments and other covariates. Risk factors for an incomplete relapse recovery were analysed in a logistic regression model with adjustments for sex, age and EDSS score (prior to relapse), as well as for functional systems involved in the relapse. Odds ratios are displayed with 95% CIs; odds ratios significantly (<1) indicate risk factors for an incomplete recovery. (B) The number of patients noted in each panel corresponds to the number of patients with relapses and status of recovery available. The charts represent the mean probability of a complete relapse recovery by phenotype (top row RRMS, bottom row SPMS), sex, pre-existing level of disability (categorized) and as a function of the patient’s age at the time of the relapse. Relapse recovery was analysed in a logistic regression model with adjustments for sex, age and EDSS score (prior to relapse). Data for the phase 3 trials and the placebo-controlled phase 3 trials are presented in Supplementary Fig. 4 and are broadly consistent.