Figure 3.

Predicted regulatory network in the older adults. A regulatory network showing the different proteins that could be playing a role in downstream effects of excess neutrophil degranulation in E-ALF. Each molecule is accompanied by higher detected log₂ fold changes (red), or lower predicted activation Z-scores (green). Illustration created with BioRender (https://biorender.com/). ARHGAP4, Rho GTPase activating protein 4; SRF, serum response factor; MRTFA/B, myocardin-related transcription factor A/B; MMPs, matrix metalloproteinases; PRTN3, myeloblastin; ELNE, neutrophil elastase; DEF1, neutrophil defensin 1; CAMP, cathelicidin antimicrobial peptide; and NGAL, neutrophil gelatinase-associated lipocalin.