Table 2. IPA ‘Diseases and Functions’ differences between Suhrbier 2 dpi vs. Winkler 2 dpi.
| Diseases and Functions | Suhrbier z-score | Winkler z-score | Delta z |
|---|---|---|---|
| Homing of leukocytes | 5.937 | 0 | 5.937 |
| Recruitment of blood cells | 5.72 | 0 | 5.72 |
| Phagocytosis of leukocytes | 5.499 | 0 | 5.499 |
| Metabolism of reactive oxygen species | 5.33 | 0 | 5.33 |
| Homing of granulocytes | 5.228 | 0 | 5.228 |
| Chemotaxis of granulocytes | 5.228 | 0 | 5.228 |
| Stimulation of cells | 4.991 | 0 | 4.991 |
| Homing of neutrophils | 4.827 | 0 | 4.827 |
| Maturation of blood cells | 4.719 | 0 | 4.719 |
| Migration of lymphatic system cells | 4.606 | 0 | 4.606 |
| Endocytosis by eukaryotic cells | 4.582 | 0 | 4.582 |
| Cell viability of blood cells | 4.518 | 0 | 4.518 |
| Cytotoxicity of cells | 4.451 | 0 | 4.451 |
| Activation of lymphatic system cells | 4.308 | 0 | 4.308 |
| Cell viability of leukocytes | 4.276 | 0 | 4.276 |
| Activation of granulocytes | 4.116 | 0 | 4.116 |
| Differentiation of T lymphocytes | 4.069 | 0 | 4.069 |
| Inhibition of blood cells | 4.057 | 0 | 4.057 |
| Binding of endothelial cells | 4.02 | 0 | 4.02 |
| Response of lymphocytes | 4.016 | 0 | 4.016 |
| Adhesion of immune cells | 6.73 | 2.722 | 4.008 |
| Recruitment of lymphocytes | 3.98 | 0 | 3.98 |
| Adhesion of blood cells | 6.635 | 2.66 | 3.975 |
| Replication of Flaviviridae | 0 | -3.959 | 3.959 |
| Binding of blood cells | 6.836 | 2.888 | 3.948 |
| Homeostasis of leukocytes | 3.865 | 0 | 3.865 |
| Cell movement of lymphatic system cells | 3.849 | 0 | 3.849 |
| Inhibition of cells | 3.83 | 0 | 3.83 |
| Degranulation | 3.826 | 0 | 3.826 |
DEGs for Suhrbier 2 dpi vs. Winkler 2 dpi. were separately analyzed by Diseases and Functions feature of IPA. Diseases and Functions were ranked by the difference in z-scores (Delta z), with the top 30 with the largest differences shown. Any Diseases and Functions that were not significant were given a z-score of 0. Diseases and Functions associated with leukocyte migration are highlighted in grey. On 2 dpi viral loads in lungs were comparable for Suhrbier and Winkler.