Table 2. Study dose titration in PIONEER-HF.

• Starting dose level based on SBP algorithm
	- If SBP 100 to <120 mmHg: sacubitril-valsartan 24/26 mg or enalapril 2.5 mg twice daily
	- If ≥120 mmHg: sacubitril-valsartan 49/51 mg or enalapril 5 mg twice daily
• At week 1, dose titrated upwards if SBP >110 mmHg
• At week 2,4,6, dose titrated upwards if SBP >100 mmHg
• Target dose
	- Sacubitril-valsartan 97/103 mmHg or enalapril 10 mg twice daily
• Clinical assessment and judgment permitted

PIONEER-HF = Comparison of Sacubitril-Valsartan versus Enalapril on Effect on N-terminal pro-B-type natriuretic peptide (NT-proBNP) in Patients Stabilized from an Acute Heart Failure Episode; SBP = systolic blood pressure.