TABLE 2.
Parameter Estimates by Generalized Linear Mixed Model of Chromosome Breaks and Exchanges at 3 Months in HYPO and rhTSH Groups
| Variable | Mean ± SE | 95% CI | Exp (mean) | % chance | P |
|---|---|---|---|---|---|
| Chromosome breaks at 3 mo in HYPO patients* | |||||
| Anti-ROMsS at 1 wk | −0.003 ± 0.001 | −0.005 to −0.00005 | 1.00 | −0.3 | 0.046 |
| Exposure rate at 48 h | 0.06 ± 0.02 | 0.01 to 0.10 | 1.06 | 6.2 | 0.016 |
| Chromosome exchanges at 3 mo in HYPO patients† | |||||
| Anti-ROMsS at 1 wk | −0.009 ± 0.003 | −0.02 to −0.002 | 0.99 | −0.9 | 0.015 |
| DNA-1 | 0.82 ± 0.34 | 0.10 to 1.54 | 2.28 | 127.5 | 0.027 |
| Exposure rate at 48 h | 0.06 ± 0.03 | 0.002 to 0.12 | 1.06 | 6.2 | 0.046 |
| Chromosome breaks at 3 mo in rhTSH patients‡ | |||||
| DNA-2 | 0.67 ± 0.25 | 0.03 to 1.31 | 1.95 | 95.4 | 0.04 |
*
Covariate: age, sex, breaks at baseline, d-ROMs at baseline and 1 wk, anti-ROMsF at baseline and 1 wk, anti-ROMsS at baseline, DNA-1, DNA-2, and epi-GFR.
†Covariate: age, sex, exchanges at baseline, d-ROMs at baseline and 1 wk, anti-ROMsF at baseline and 1 wk, anti-ROMsS at baseline, DNA-2, and epi-GFR.
‡Covariate: age, sex, breaks at baseline, d-ROMs at baseline and 1 wk, anti-ROMsF at baseline and 1 wk, anti-ROMsS at baseline and 1 wk, DNA-1, dosimetry at 48 h, and epi-GFR.
Exp (mean) = exponential of the mean.