Figure 1.
Comparisons of genetic and sex effects on protein abundance among the CC, DO, and founder strains reveal strong concordance
(A) The CC strains and DO mice are descended from the same eight inbred founder strains. Mutations occur during the breeding generations of the CC and DO mice and can become fixed in the CC strains.
(B) Venn diagram of the proteins analyzed in the CC, DO, and founder strains. The founder strains and DO samples were obtained in the same experiment, resulting in greater overlap.
(C) Estimates of heritability of protein abundance are greater on average in the inbred CC and founder strains compared with DO mice. Vertical lines represent the median heritability in each population.
(D–F) Sex effects for protein abundances in (D) CC versus DO, (E) CC versus founder strains, and (F) DO versus founder strains. The solid identity line and dashed horizontal and vertical lines at 0 are included for reference. Pearson correlation coefficients (r) between the sex effects of the populations and corresponding p values included. A breakdown of the direction of sex effects is shown for each comparison of populations. N.S. indicates proteins that did not have significant sex effects at FDR < 0.1. χ2 test of independence used to evaluate consistency of the direction of sex effects.