. 2022 Feb 2;61(10):4155–4162. doi: 10.1093/rheumatology/keac015

Table 1.

Definitions of lymphocyte subsets

Subset	Definition
T cells	CD3⁺
CD4 T cells	CD3⁺CD4⁺CD8⁻
CD8 T cells	CD3⁺CD4⁻CD8⁺
Naïve CD4 T cells	CD4⁺CD27⁺CD62L⁺CD45RA⁺CD45RO⁻
Central memory CD4 T cells	CD4⁺CD27⁺CD62L⁺CD45RA⁻CD45RO⁺
Effector memory CD4 T cells	CD4⁺CD27⁻CD62L⁻CD45RA⁻CD45RO⁺
Naïve CD8 T cells	CD8⁺CD27⁺CD62L⁺CD11a^lowCD45RO⁻
Central memory CD8 T cells	CD8⁺CD27⁺CD62L⁺CD11a^highCD45RO⁺
Effector memory CD8 T cells	CD8⁺CD27⁻CD62L⁻CD11a^highCD45RO⁺
Effector CD8 T cells	CD8⁺CD27⁻CD62L⁻CD11a^highCD45RO⁻
Activated T cells	CD3⁺CD25^lowCD69⁺
Activated CD4 T cells	CD3⁺CD4⁺CD25^lowCD69⁺
Recent thymic CD4 emigrants	CD3⁺CD4⁺CD45RA⁺CD45RO⁻CD31⁺
γ/δ T cells	CD3⁺δ,γ⁺
Induced Th1 CD4 T cells	CD3⁺CD4⁺CD8⁻IFN-γ⁺IL-4⁻ with PMA/ionomycin stimulation
Induced Th2 CD4 T cells	CD3⁺CD4⁺CD8⁻IFN-γ⁻IL-4⁺ with PMA/ionomycin stimulation
Induced Tc1 CD8 T cells	CD3⁺CD4⁻CD8⁺IFN-γ⁺IL-4⁻ with PMA/ionomycin stimulation
Induced Tc2 CD8 T cells	CD3⁺CD4⁻CD8⁺IFN-γ⁻IL-4⁺ with PMA/ionomycin stimulation
B cells	CD19⁺
Naïve B cells	CD19⁺CD27⁻
Non-isotype-switched memory B cells	CD19⁺CD27⁺IgM⁺IgD⁺
Isotype-switched memory B cells	CD19⁺CD27⁺IgM⁻IgD⁻
Myeloid dendritic cells/precursors	CD11c⁺HLADR⁺lineage-^a
Plasmacytoid dendritic cells/precursors	CD11c⁻CD123⁺HLADR⁺lineage-^a
Treg cells	CD3⁺CD4⁺CD25⁺FoxP3⁺
Treg cells/CD127⁻	CD3⁺CD4⁺CD25⁺FoxP3⁺CD127⁻

Not expressing lineage-specific markers (CD3, CD14, CD16, CD19 or CD56).