Table 1.
Demographic and clinical characteristics of patients with MDD and HC
| Characteristics | MDD (N=44) | HC (N=44) | Significance (p) |
|---|---|---|---|
| Age (yr) | 37.61±12.85 | 37.36±12.44 | 0.926 (t=0.093) |
| Sex (F/M) | 30/14 | 31/13 | 0.817 (χ2=0.053) |
| Education level | |||
| Elementary and middle school | 1 | 7 | |
| High school or college/university | 40 | 35 | 0.081 (χ2=5.033) |
| Above graduate school | 3 | 2 | |
| HDRS-17 score | 19.05±5.47 | 0.59±1.44 | <0.001 (t=21.636) |
| Duration of illness (mon) | 50.66±90.05 | NA | NA |
| Drug-naïve/medicated patients | 30/14 | NA | NA |
| Medication (N) | 14 | NA | NA |
| SSRI | 5 | ||
| SNRI | 5 | ||
| Other AD | 0 | ||
| Combination of ADs | 4 | ||
| C4BPA | 29.85±0.77 | 28.05±1.01 | 89.99* (p<0.001) |
| C4BPB | 26.57±0.76 | 24.77±1.05 | 86.06* (p<0.001) |
Significance was examined using independent t-test, chi-squared test, and one-way analysis of covariance.
*
denotes significance.
MDD, major depressive disorder; HC, healthy control; HDRS-17, 17-item Hamilton Depression Rating Scale; SSRI, selective serotonin reuptake inhibitor; SNRI, serotonin and norepinephrine reuptake inhibitor; combination of AD, combinations of two or more types of antidepressant; ADs, antidepressants; C4BPA, C4-binding protein alpha chain; C4BPB, C4-binding protein beta chain