Figure 4.

USP15 protein-protein interaction in BRCA. (a, b) Interaction network of USP15 gene derived from STRING and GeneMANIA. STRING and GeneMANIA show the interactions for genes linked with each other according to physical interaction, genetic interactions, coexpression, pathway, colocalization, and shared protein domain (c) USP15 correlation analysis; data from GEPIA (d) Immunoprecipitation experiments verify the interaction between USP15 and the Smad protein. (e) Schematic diagram of the structure in which USP15 functions (f) Correlation between USP15 and different proteins, data from TIMER.