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. 2022 Oct 6;13:5895. doi: 10.1038/s41467-022-33511-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Total effects against cell-composition-mediated effects of CMV infection on 5mC levels. b Effects of CD4⁺ T cell differentiation on 5mC levels against cell-composition-mediated effects of CMV infection on 5mC levels. c Proportion of CD8⁺ T_EMRA cells in CMV^– and CMV⁺ donors (left panel). 5mC levels at the DNMT3A locus against the proportion of CD8⁺ T_EMRA cells (right panel). 5mC levels are given in the β value scale. The black line indicates the linear regression line. d Genomic distribution of direct effects of CMV infection at the LTBP3 locus. e Enrichment of CpG sites with a significant direct, positive effect of CMV infection in binding sites for TFs. f Enrichment of CpG sites with a significant direct, negative effect of CMV infection in binding sites for TFs. a, b Only CpG sites with a significant cell-composition-mediated effect are shown. The black line indicates the identity line. Tests were corrected for multiple testing by the Bonferroni adjustment. a, b, d Effect sizes are given in the M value scale. e, f The 15 most enriched TFs are shown, out of 1165 tested TFs. The point and error bars indicate the odds-ratio and 95% CI. CIs were estimated by the Fisher’s exact method. Statistics were computed based on a sample size of n = 884 and for 644,517 CpG sites.