Table 3.
Subgroup analysis of the association of SUA with the risk of CRC.
| T1 group | T2 group | T3 group | ||||
|---|---|---|---|---|---|---|
| Case/person-years | Adjusted HRs (95% CI) | Case/person-years | Adjusted HRs (95% CI) | Case/person-years | Adjusted HRs (95% CI) | |
| Sex | ||||||
| Womena | 22/78,877 | Ref | 30/79,804 | 1.07 (0.62, 1.87) | 32/76,883 | 1.25 (0.72, 2.17) |
| Menb | 142/306,682 | Ref | 158/303,602 | 1.11 (0.90, 1.38) | 199/296,223 | 1.58 (1.10, 2.51) |
| p for interaction | 0.962 | |||||
| Age (years) | ||||||
| Age ≤ 45 | 17/133,763 | Ref | 19/118,813 | 1.82 (0.96, 3.44) | 21/108,964 | 2.00 (1.10, 3.64) |
| 45 < Age ≤ 65 | 114/218,372 | Ref | 119/223,301 | 1.55 (0.87, 2.99) | 147/201,233 | 1.76 (1.22, 2.14) |
| Age > 65 | 33/33,424 | Ref | 50/41,294 | 1.68 (0.64, 4.42) | 63/62,909 | 1.70 (0.68, 4.26) |
| p for interaction | 0.338 | |||||
| BMI (kg/m2) | ||||||
| BMI < 24 | 83/228,576 | Ref | 82/188,049 | 1.82 (0.96, 3.44) | 83/132,987 | 1.98 (1.08, 3.60) |
| 24 ≤ BMI < 28 | 63/125,979 | Ref | 70/137,704 | 1.20 (0.66, 2.20) | 87/157,283 | 1.21 (0.69, 2.13) |
| BMI ≥ 28 | 18/31,004 | Ref | 36/57,653 | 1.68 (0.64, 4.42) | 61/82,836 | 1.78 (0.73, 4.29) |
| p for interaction | 0.951 | |||||
All models were adjusted for age, sex, BMI, TG, TC, CRP, TBIL, ALT, diabetes, hypertension, family income, educational background, marital status, salt consumption, current smoker, drinking status, physical activity, chronic kidney disease, and family history of cancer except the stratified factors.
aThe cut-offs of the SUA among females were 211.00 and 267.00 μmol/L, respectively.
bThe cut-offs of the SUA among males were 262.00 and 329.00 μmol/L, respectively.