Table 3.
Prognostic factor for mortality in 294 patients with ILDs.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Age | 1.010 | 0.991–1.028 | 0.300 | – | – | – |
| Sex, male | 1.356 | 0.822–2.237 | 0.233 | – | – | – |
| Smoking | 1.254 | 0.780–2.015 | 0.351 | |||
| PFT | ||||||
| FVC (%) | 0.963 | 0.949–0.978 | < 0.001 | 0.959 | 0.944–0.975 | < 0.001 |
| DLCO (%) | 0.990 | 0.976–1.004 | 0.149 | |||
| ILD type, IPF | 1.754 | 1.101–2.796 | 0.018 | 2.235 | 1.230–4.063 | 0.008 |
| Tumor markers | ||||||
| CEA | 2.482 | 1.522–4.049 | < 0.001 | 2.323 | 1.271–4.248 | 0.006 |
| CA 19-9 | 2.540 | 1.230–5.247 | 0.012 | |||
| CA 125 | 6.624 | 1.238–35.446 | 0.027 | |||
HR hazard ratio, CI confidence interval, IPF idiopathic pulmonary fibrosis, ILD interstitial lung disease, PFT pulmonary function test, FVC forced vital capacity, DLCO diffusing capacity of the lung for carbon monoxide, ILD interstitial lung disease, CEA carcinoembryonic antigen, CA carbohydrate antigen.