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. 2022 Sep 23;9:971621. doi: 10.3389/fmolb.2022.971621

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Copyright © 2022 Wijesinghe, Anderson, Brown, Nanus, Housmans, Green, Hackl, Choi, Arkill, Welting, James, Jones and Peffers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Senescent EVs are characterized by differentially expressed miRNAs. (A) Small RNA sequencing percentage read counts of diverse EV RNA content including snoRNAs, snRNAs, tRNAs, lncRNA, yRNA, scRNA, mRNAs, rRNAs and microRNAs, with tRNAs being the most abundant (N = 6). (B) Heatmap of 50 differentially expressed miRNAs (p < 0.25). (C) Volcano plot of log fold change versus–log (p-value) of miRNAs with 17 miRNAs of interest annotated. See Table 1. (D) IPA canonical pathway enrichment analysis of miRNAs. (E) Network analysis predictions for cell proliferation pathway. (F) IPA functional annotation of 116 genes identified by miRNet to be targets of the 17 DEG miRNAs identified. See Supplementary Table S2 for miRNA targets. (G) IPA upstream regulator analysis of predicted target genes and DEG miRNAs identified.