Table 2.
Potential cross-reactive epitopes between SARS-CoV-2 proteins and food antigens.
| SARS-CoV-2 antigen | SARS-CoV-2 sequence | Mapped start to end | Food sequence | ID (%) | |
|---|---|---|---|---|---|
|
Peanut
ARA H2 allergen |
The crystal structure of COVID-19 main protease in the apo state | TITVNVLAWLY–AA | 197-209 | TILV-ALA-LFLLAA* | 53 |
| Chain A, Spike glycoprotein | LVSL-LSVLL | 15-23 | LVALALF-LL* | 60 | |
| Chain A, Spike glycoprotein | SQILPDPSKPS | 777-787 | SQ—DPYSPS* | 55 | |
| Chain A, Spike glycoprotein | SPS—–GAGSVASQ | 699-709 | SPSPYDRRGAGS–SQ* | 56 | |
| Replicase ORF1a polyprotein | LVA-EWFL-A | 2323-2330 | LVALALFLLA* | 60 | |
| Replicase ORF1a polyprotein | MPILTLTRAL | 4634-4643 | MAKLTILVAL | 50 | |
| Membrane glycoprotein | KLIFLWLLWPVTLACFVLAA | 50-69 | KLTIL—–VALALFLLAA | 50 | |
| Structure of Disulphide-stabilized SARS-CoV-2 Spike Protein Trimer (x2 disulphide-bond mutant, G413C, V987C, single Arg S1/S2 cleavage site) | CEAEVQI—–DRL | 978-987 | CEALQQIMENQSDRL | 53 | |
| α−gliadin | Structure of SARS-CoV-2 3Q-2P full-length prefusion spike trimmer (C3 symmetry), SARS-CoV-2 | PQ-QAQSVASQ | 681-690 | PQLQPQN-PSQ | 55 |
| Chain A, Spike protein S2, SARS-CoV-2 | QSLQTYVTQQ | 300-309 | QILQ—–QQ* | 50 | |
| Chain A, Spike protein S2, SARS-CoV-2 | QQLIRAAEIRASANLA | 308-323 | QQLPQFEEIR—NLA* | 56 | |
| Chain A, Spike protein S1, SARS-CoV-2 | SLV-SLLSVLL | 14-23 | SLVSSLVSMIL* | 64 | |
| Chain A, Spike protein S1, SARS-CoV-2 | PALLSLV-SLLSVL | 10-22 | PAQLEVIRSL–VL* | 50 | |
| Glutenin | Chain A, Spike glycoprotein, SARS-CoV-2 | EVAKNLNESL | 1185-1194 | EVQANL–SL* | 50 |
| Chain A, Spike protein S1, SARS-CoV-2 | STNLVK–NKGSLE | 215-226 | STNLQKALSK-ALE | 57 | |
| Chain A, Nucleoprotein, SARS-CoV-2 | DLKFPRG-QG | 16-24 | NLDFSKGHQG* | 50 | |
| Chain A, Spike glycoprotein, SARS-CoV-2 | TQTNSPASVASQSI | 676-689 | TQTPTQAS-NSQFI | 57 | |
| Chain A, Spike glycoprotein, SARS-CoV-2 | TRTQLPPAYTNS | 20-31 | TPTQ—A-SNS* | 50 | |
| Chain A, Spike glycoprotein, SARS-CoV-2 | IQHSG–RPLESR | 1246-1256 | 1HHPGAFPPLPSR* | 54 | |
| Rice endochiti-nase | Chain A, Spike glycoprotein, SARS-CoV-2 | RASANLAAIKIM | 1019-1029 | RALA-LAVVAM* | 55 |
| Chain B Spike glycoprotein, SARS-CoV-2 | RASANLAATKM | 1111-1121 | RALA-LAVVAM* | 55 | |
| Chain A, Spike glycoprotein, SARS-CoV-2 | GGG—–SGGGSGGSS | 1261-1272 | GGGPTPPSSGGGSGVAS* | 59 | |
| Chain A, Spike glycoprotein, SARS-CoV-2 | SGAGS-VASQSII | 701-712 | SGGGSGVA–SII* | 69 | |
| Chain R, Spike protein S1, SARS-CoV-2 | CGGG——GSGSG | 219-227 | CGGGPTPPSSGGGSG | 53 | |
| Chain A, Spike glycoprotein, SARS-CoV-2 | PSSA-SSVASQSII | 681-693 | PSSGGGSGVAS–II | 60 | |
| Chain A, Spike glycoprotein, SARS-CoV-2 | SPGGSGSVASQSII | 667-680 | SSGGGSGVA–SII | 57 | |
| Chain A, Spike glycoprotein, SARS-CoV-2 | GSGSGRVQPTESIV | 1-14 | GGGSG-V—ASII | 50 | |
| α-casein | Chain A, Spike protein S2, SARS-CoV-2 | LQSLQTYVTQQLIR | 299-312 | LQ-LQAAHAQEQIR* | 50 |
| Dynorphin | Chain A, Spike glycoprotein, SARS-CoV-2 | TPSALGKLQD | 915-924 | TPSTLG-LND* | 70 |
| Peanut agglutinin | Chain A, Spike glycoprotein, SARS-CoV-2 | TQCVNLTTRTQLPP | 4-17 | TQHPNVTT—LAP* | 50 |
| Chain A, Spike glycoprotein, SARS-CoV-2 | CSFGGVSVITP | 564-574 | CS—VSTATP* | 55 | |
| Chain A, Spike protein S2, SARS-CoV-2 | FIAGLIAVLV | 4-14 | FIGG—IVLV | 64 | |
| Wheat germ agglutinin | Chain B Spike glycoprotein, SARS-CoV-2 | VLSHHFGKEL | 72-81 | VLSQKFEKEL | 70 |
| Chain A, Spike glycoprotein, SARS-CoV-2 | LVKQLSSNFG | 53-62 | LVIQLKESFG* | 60 | |
| Chain A, Spike glycoprotein, SARS-CoV-2 | TGD—VNLTTRT | 19-28 | TGNIARVNLTTNT | 62 | |
| Chain A, Spike glycoprotein, SARS-CoV-2 | PSAYTNSF-TRGV | 25-36 | PSA-SNAFMVCGV | 54 | |
| Lentil lectin | Chain A, Spike protein S2, SARS-CoV-2 | SLQTYVTQQLI | 301-311 | SLQT—QMI* | 55 |
| Chain A, Spike glycoprotein, SARS-CoV-2 | NGLTVLPPLLT | 830-84 | NVLTVT—LT* | 55 | |
| Pineapple bromelain | Chain A, Spike glycoprotein, SARS-CoV-2 | VASQSIIAYT | 674-683 | VA-Q—YT* | 50 |
| Chain A, Spike protein S1, SARS-CoV-2 | KRFDNPVLPFND | 64-75 | KR—EPVVSFDD* | 50 | |
| Chain A, Spike glycoprotein, SARS-CoV-2 | KQGNFKNLSE | 182-191 | KRGNLVSLSE* | 60 | |
| Chain A, Spike protein S2, SARS-CoV-2 | VTQQLIRAAEIRASAN | 306-321 | VSNQPI-AAALDASGN* | 50 | |
| Chain A, Spike protein S2, SARS-CoV-2 | HFPREGVFVSN-GT | 386-398 | HYKR-GVFTGPCGT* | 50 | |
| Chain A, Nucleoprotein, SARS-CoV-2 | QDPNSSSTKK | 11-20 | QD—SSGKK | 60 | |
| Almond allergen | Chain E, Spike protein S1, SARS-CoV-2 | FVF-LVLLPLV | 2-11 | FVFSLCLL-LV* | 73 |
| Chain B, Spike glycoprotein, SARS-CoV-2 | AFFFFLQLLGNVLV | 57-70 | AFVFSLCLL—LV | 57 | |
| Chain A, Spike protein S2, SARS-CoV-2 | GINASVVNIQ | 4-13 | GVAASRITIQ* | 50 | |
| Chain A, Spike glycoprotein, SARS-CoV-2 | QELGKYEQGSG | 1188-1198 | QE—QQGSG* | 55 | |
| Chain A, Spike protein S1, SARS-CoV-2 | NENGTITDAVDCALD | 268-282 | NENG—DAI—LD* | 53 | |
| Chain A, Spike glycoprotein, SARS-CoV-2 | YQTQTNSRRRAR | 672-683 | YQI—SREQAR* | 50 | |
* This subject sequence made a match with more than one section of the SARS-CoV-2 sequence. Only a selection of the overwhelming number of matches are shown in this table, with a cutoff of ID% of 50 and above.