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. 2022 Oct 6;12:16718. doi: 10.1038/s41598-022-20877-2

Table 2.

Odds ratios for body adipose tissue and TNM stage (stage I as referent) and Fuhrman grade (grade 1 as referent) for males and females separately.

TNM stage
Stage I is referent
Univariable analysis Multivariable analysis
Stage II
OR (95% CI)
Stage III
OR (95% CI)
Stage IV
OR (95% CI)
Stage II
OR (95% CI)
Stage III
OR (95% CI)
Stage IV
OR (95% CI)
Males
BMIa, kg/m2 1.02 (0.95–1.09) 0.93 (0.87–0.98)* 0.90 (0.86–0.95)*** 1.09 (0.95–1.25) 0.97 (0.87–1.08) 1.03 (0.93–1.14)
VATa, per 10 cm2 0.99 (0.96–1.01) 0.97 (0.95–0.99)* 0.94 (0.92–0.96)*** 0.97 (0.93–1.00) 0.98 (0.95–1.01) 0.93 (0.91–0.96)***
SATa, per 10 cm2 1.01 (0.97–1.04) 0.97 (0.94–1.00) 0.96 (0.94–0.99)* 0.99 (0.94–1.05) 1.00 (0.96–1.05) 1.01 (0.96–1.05)
TATb, per 10 cm2 1.00 (0.98–1.01) 0.98 (0.97–1.00)* 0.97 (0.95–0.98)*** 0.97 (0.94–1.01) 0.98 (0.96–1.01) 0.95 (0.93–0.98)***
rVATb, in % 0.99 (0.97–1.01) 0.99 (0.98–1.01) 0.97 (0.96–0.98)*** 0.99 (0.97–1.01) 0.99 (0.98–1.01) 0.97 (0.96–0.99)***
Females
BMIa, kg/m2 0.96 (0.88–1.03) 0.96 (0.90–1.03) 0.91 (0.86–0.97)** 0.99 (0.85–1.15) 1.01 (0.89–1.15) 0.99 (0.88–1.11)
VATa, per 10 cm2 0.97 (0.93–1.02) 0.98 (0.94–1.02) 0.95 (0.92–0.99)** 0.98 (0.91–1.06) 0.96 (0.90–1.02) 0.95 (0.89–1.00)*
SATa, per 10 cm2 0.98 (0.94–1.01) 0.98 (0.95–1.01) 0.96 (0.93–0.98)** 0.99 (0.93–1.05) 1.00 (0.94–1.05) 0.99 (0.94–1.03)
TATb, per 10 cm2 0.99 (0.96–1.01) 0.99 (0.97–1.01) 0.97 (0.96–0.99)*** 0.99 (0.94–1.03) 0.98 (0.94–1.02) 0.97 (0.94–1.00)
rVATb, in % 0.99 (0.97–1.02) 1.00 (0.97–1.02) 0.99 (0.97–1.01) 0.99 (0.96–1.02) 0.99 (0.96–1.01) 0.98 (0.96–1.00)
Fuhrman grade
Grade 1 is referent
Univariable analysis Multivariable analysis
Grade 2
OR (95% CI)
Grade 3 + 4
OR (95% CI)
Grade 2
OR (95% CI)
Grade 3 + 4
OR (95% CI)
Males
BMIa, kg/m2 1.03 (0.98–1.08) 0.99 (0.94–1.04) 0.96 (0.88–1.06) 0.98 (0.89–1.08)
VATa, per 10 cm2 1.01 (1.00–1.03) 0.99 (0.97–1.00) 1.03 (1.00–1.05) 0.99 (0.96–1.02)
SATa, per 10 cm2 1.02 (0.99–1.05) 1.01 (0.98–1.03) 1.01 (0.97–1.05) 1.02 (0.98–1.06)
SATa, high vs low 1.51 (1.03–2.22)* 0.95 (0.65–1.38) 1.14 (0.72–1.82) 0.94 (0.60–1.47)
TATb, per 10 cm2 1.01 (1.00–1.02) 0.99 (0.98–1.01) 1.02 (1.00–1.05) 1.00 (0.98–1.02)
rVATb, in % 1.00 (0.99–1.01) 0.99 (0.97–1.00) 1.01 (0.99–1.02) 0.99 (0.94–1.05)
Females
BMIa, kg/m2 1.02 (0.97–1.07) 0.98 (0.93–1.03) 0.97 (0.88–1.07) 1.02 (0.92–1.14)
VATa, per 10 cm2 1.01 (0.98–1.04) 0.97 (0.94–1.01) 1.03 (0.98–1.08) 1.00 (0.95–1.05)
SATa, per 10 cm2 1.01 (0.99–1.04) 0.99 (0.96–1.01) 1.01 (0.97–1.05) 0.98 (0.93–1.02)
SATa, high vs low 1.39 (0.87–2.22) 0.59 (0.36–0.98)* 1.10 (0.59–2.06) 0.51 (0.26–0.99)*
TATb, per 10 cm2 1.01 (0.99–1.02) 0.99 (0.97–1.01) 1.02 (0.99–1.05) 0.99 (0.96–1.02)
rVATb, in % 0.99 (0.97–1.01) 0.98 (0.97–1.00) 1.00 (0.98–1.02) 1.00 (0.98–1.03)

BMI, body mass index; VAT, visceral adipose tissue; SAT, subcutaneous adipose tissue; TAT, total adipose tissue; rVAT, relative visceral adipose tissue; OR, odds ratio; CI, confidence interval.

*p-value < 0.05; **p-value < 0.01; ***p-value < 0.001.

aMultivariable models are adjusted for age and mutually adjusted for BMI, VAT and SAT; bMultivariable models are adjusted for age and BMI.