Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
In vitro cytotoxic activity of 12d and 12i against tumor cells, MDA-MB-468 and CCRF-CM under hypoxic conditions (1%O2, 5% CO2 and 94% N2) compared to staurosporine.
| Compound | IC50 (µM)* | |
|---|---|---|
| MDA-MB-468 | CCRF-CM | |
| 12d | 3.99 ± 0.21 | 4.51 ± 0.24 |
| 12i | 1.48 ± 0.08 | 9.83 ± 0.52 |
| Staurosporine | 6.07 ± 0.03 | 2.17 ± 0.11 |
*The mean ± S.D. of three experiments.
