Table 3.
ROC curves for the prediction of HBsAg loss in patients.
| Parameter | ROC curves | Comparison of AUC for indicators | |||||||
|---|---|---|---|---|---|---|---|---|---|
| AUC | 95% CI | cut-off | sensitivity | specificity | indicators | difference between AUC | p value | 95% CI | |
| Baseline | |||||||||
| Total HBsAg (a) | 0.654 | 0.521 - 0.773 | 114.7 | 61.54 | 66.67 | – | – | – | – |
| LHBs (b) | 0.827 | 0.707 - 0.912 | 13.99 | 87.18 | 61.90 | a vs.b | 0.172 | 0.072 | -0.016 - 0.360 |
| MHBs (c) | 0.887 | 0.779 - 0.954 | 7.95 | 100.00 | 71.43 | a vs.c | 0.233 | 0.014 | 0.048 - 0.417 |
| Combination factor 1(d) | 0.922 | 0.823 - 0.975 | -0.83 | 100.00 | 85.71 | a vs.d | 0.267 | 0.004 | 0.087 - 0.448 |
| After 12 weeks of treatment | |||||||||
| Total HBsAg (e) | 0.755 | 0.626 - 0.857 | 29.57 | 69.23 | 71.43 | – | – | – | – |
| LHBs (f) | 0.896 | 0.790 - 0.960 | 11.44 | 84.62 | 85.71 | e vs.f | 0.142 | 0.082 | -0.018 - 0.301 |
| MHBs (g) | 0.863 | 0.750 - 0.938 | 5.84 | 64.10 | 100.00 | e vs.g | 0.109 | 0.179 | -0.050 - 0.267 |
| Combination factor 2(h) | 0.939 | 0.846 - 0.984 | 1.00 | 82.05 | 100.00 | e vs.h | 0.184 | 0.015 | 0.037 - 0.332 |
| Change from baseline at 12 weeks | |||||||||
| The reduction in total HBsAg (i) | 0.691 | 0.559 - 0.804 | 0.29 | 74.36 | 61.90 | – | – | – | – |
| The reduction in LHBs (j) | 0.711 | 0.580 - 0.821 | 0.07 | 69.23 | 76.19 | i vs.j | 0.020 | 0.837 | -0.172 - 0.212 |
| The reduction in MHBs (k) | 0.507 | 0.374 - 0.638 | 0.17 | 84.62 | 4.76 | i vs.k | 0.184 | 0.091 | -0.029 - 0.398 |
| ALT>1.5×ULN(l) | 0.637 | 0.503 - 0.758 | 0.00 | 51.28 | 76.19 | i vs.l | 0.054 | 0.572 | -0.133 - 0.240 |
HBsAg, Hepatitis B surface antigen; LHBs, large hepatitis B surface proteins; MHBs, middle hepatitis B surface proteins; ALT, alanine aminotransferase; ULN, upper limit of normal; AUC, area under the curve; CI, confidence interval.