. 2022 Sep 23;9:1000846. doi: 10.3389/fcvm.2022.1000846

Table 1.

Inclusion and exclusion criteria.

Inclusion criteria	Exclusion criteria
- Patients aged 18 to 85 years - First HER2 positive breast cancer, confirmed histologically - WHO Performance status ≤ 1 - Completed chemo-radiotherapy - Normal renal function (creatinine clearance ≥ 60 ml.min⁻¹) - Normal heart function with LVEF ≥ 50% (As assessed by echocardiography dating from less than 3 months previously) - Normal liver function (normal ASAT and ALAT) - Certificate of non-contraindication to the practice of physical activity - Active contraception or menopaused	- HER2 negative breast cancer - Patients with metastases - Heart failure (LVEF ≤ 50%) - Resting oxygen saturation (SaO₂) ≤ 92% - Autoimmune disease (systemic lupus erythematosus, rheumatoid arthritis) - Symptomatic osteoarthritis, cardiovascular disease (angina or uncontrolled hypertension) or lung disease (chronic obstructive pulmonary disease) - Patients suffering from malnutrition (BMI < 18 kg.m⁻²) or weight loss of >10% during the previous 3 months - Patients with psychiatric or cognitive disorders deemed unsuitable for physical activity - Pregnant or breastfeeding patients

Inclusion criteria

Exclusion criteria

- Patients aged 18 to 85 years
- First HER2 positive breast cancer, confirmed histologically
- WHO Performance status ≤ 1
- Completed chemo-radiotherapy
- Normal renal function (creatinine clearance ≥ 60 ml.min⁻¹)
- Normal heart function with LVEF ≥ 50% (As assessed by echocardiography dating from less than 3 months previously)
- Normal liver function (normal ASAT and ALAT)
- Certificate of non-contraindication to the practice of physical activity
- Active contraception or menopaused

- HER2 negative breast cancer
- Patients with metastases
- Heart failure (LVEF ≤ 50%)
- Resting oxygen saturation (SaO₂) ≤ 92%
- Autoimmune disease (systemic lupus erythematosus, rheumatoid arthritis)
- Symptomatic osteoarthritis, cardiovascular disease (angina or uncontrolled hypertension) or lung disease (chronic obstructive pulmonary disease)
- Patients suffering from malnutrition (BMI < 18 kg.m⁻²) or weight loss of >10% during the previous 3 months
- Patients with psychiatric or cognitive disorders deemed unsuitable for physical activity
- Pregnant or breastfeeding patients

ALAT, alanine aminotransferase; ASAT, aspartate transaminase; BMI, body mass index; HER2, human epidermal growth factor receptor 2; LVEF, left ventricular ejection fraction; SaO₂, oxygen arterial saturation; WHO, world health organization.