Table 4.

Summary of bioinformatic SNP annotations.

SNP ID	Gene	Alleles M/m a	MAF b	Rank c	HaploReg d	eQTL e	GTEx f
rs7787082	ABCB1	G/A	0.18	6	CRX FOXD3 GFI1	–	Testes, skin
rs3842	ABCB1	T/C	0.14	n/a	PLZF	ABCB4	Brain, nerves
rs2235023	ABCB1	C/T	0.09	6	CEBPB ISL2 POU1F1 RHOX11	ABCB1 ABCB4	Testes, muscles
rs2214102	ABCB1	C/T	0.09	4	GR	–	Heart, colon
rs2725256	ABCG2	A/G	0.33	6	FOXA HNF4 HBP1 POU1F1 RXRA STAT	SPP1	Adipocytes
rs12505410	ABCG2	T/G	0.40	4	PBX3	–	Testes, blood
rs2622621	ABCG2	C/G	0.30	5	-	–	Blood
rs3114018	ABCG2	A/C	0.49	5	LHX3 MEF2 NANOG POU2F2	–	Esophagus, heart
rs3109823	ABCG2	T/C	0.26	6	CTCF NRF-2 YY1	–	Blood
rs2307418	CAR	T/G	0.15	5	ERalpha-A GCMGR	TOMM40L USF1	Brain, muscles, skin
rs11265571	CAR	A/T	0.17	4	ERalpha-A PAX-5 RHOX11		Skin, testes, colon
rs2461818	PXR	C/T	0.08	6	ARID5B FOXO2 FOXO3 FOXP1 HDAC2 IK2 PLZF SOX6	PLA1A GSK3B	Thyroid
rs11917714	PXR	C/T	0.17	6	HIC1	GSK3B	Nerves, small intestine, esophagus, testes
rs3732357	PXR	A/G	0.35	5	GLI GLIS2 ZIC	GSK3B	Adipocytes, colon, esophagus, stomach, arteries, thyroid, brain, muscles, lungs
rs3732360	PXR	T/C	0.23	6	E2A LMO2 MYF TATA	GSK3B GPR156	Adipocytes, nerves, esophagus, brain, colon, arteries
rs3732359	PXR	A/G	0.20	6	BCL NRSF PLAG1 SIN3AK20 TAL1 YY1	GSK3B GPR156	Adipocytes, nerves, esophagus, brain, colon, arteries, thyroid

The table contains associations for all SNPs, while those that occur only in blood cells are bold.

^aM: major allele; m: minor allele.

^bMAF: minor allele frequency in the 1000 Genomes European population.

^cRank from RegulomeDB: 1 is given to SNPs showing the strongest evidence of a role in regulating the transcription process by binding transcription factors, while 6 to SNPs with a low probability of influencing to transcription.

^dHaploReg: the tested SNP probably influences the expression of mentioned genes.

^eeQTL: the tested SNP is located in the eQTL (expression quantitative trait loci) of mentioned genes.

^fGTEx: the relationship between the tested SNP and the tissue in which the gene is expressed.