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. 2022 Sep 23;13:904314. doi: 10.3389/fphar.2022.904314

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Copyright © 2022 Li, Yan, Zhao, Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fer-1 reduces sorafenib-induced heart dysfunction in mice. (A) Schematics of the overall design outline. (B) Kaplan Meier plot of survival. (C) Representative images of the heart in different groups. (D) Representative M-mode echocardiographic images of each study group. (E) Heart weight to body weight ratio (n = 6 per group) (F) EF, ejection fraction (n = 6 per group). (G) FS, fractional shortening (n = 6 per group). (H–J) Levels of col I, BNP and ANP in heart tissue (n = 3 per group). (K) The myocardial pathological damage was detected by HE staining. Scale bar, 10 μm. (L) Masson’s trichrome staining was performed on the cardiac sections for collagen fibers. Scale bar, 50 μm *p < 0.05, **p < 0.01, ***p < 0.001 vs. control group. #p < 0:05, ##p < 0.01, ###p < 0.001 vs. sorafenib group. One-way analysis of variance (ANOVA) with Tukey’s post hoc test was used for multigroup comparisons.