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. 2022 Sep 23;13:904314. doi: 10.3389/fphar.2022.904314

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Copyright © 2022 Li, Yan, Zhao, Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A scheme of the proposed mechanisms. Sorafenib treatment increases ATF3 expression by repressing Slc7a11 expression to suppress system Xc-in cardiomyocytes, and thereby predispose cells to a state prone to ferroptosis.