TABLE 2.

Immune correlates of protection.

Protection		Gross pathology				Shedding				Viremia				-1
Response (0 dpc)		NADC30	NC174	VR2332	NADC20	NADC30	NC174	VR2332	NADC20	NADC30	NC174	VR2332	NADC20	0.9 0.8
TCR-γδs	Proliferation	−0.37	−0.27	0.01	−0.42	−0.50	0.02		−0.19	−0.42	0.29	−0.17	−0.49	0.7
														0.6
	IFN-γ	−0.23	0.28	−0.26	0.46	−0.19	0.09	n.d	0.72	0.04	−0.11	0.39	0.36	0.5 0.4
CD8	Proliferation	−0.37	0.34	−0.22	−0.09	−0.61	0.20		−0.35	−0.45	0.11	−0.41	−0.31	0.3 0.2
	IFN-γ	0.26	0.54	0.46	0.11	0.27	−0.18	n.d	0.01	−0.04	−0.23	−0.22	0.21	0.1
														0
CD4	Proliferation	−0.46	0.22	−0.36	−0.48	−0.72	−0.40		−0.56	−0.64	−0.22	−0.57	−0.73	0.1 0.2
	IFN-γ	−0.36	−0.19	−0.32	−0.59	−0.75	−0.43	n.d	−0.49	−0.58	−0.17	−0.34	−0.52	0.3 0.4
	Memory	0.02	0.29	−0.13	−0.77	−0.61	−0.16		−0.40	−0.70	−0.36	−0.59	−0.74	0.5 0.6
Humoral	Local IgA	−0.28	0.24	−0.21	−0.45	−0.35	−0.01		−0.54	−0.15	−0.36	0.17	−0.60	0.7 0.8
	Systemic IgG	−0.55	0.23	−0.37	−0.59	−0.95	−0.18	n.d	−0.55	−0.73	−0.27	−0.86	−0.78	0.9 1

The table lists the R values for the correlations between various immune parameters at 0 dpc (e.g., proliferation, IFN-γ production, and differentiation into CD4 memory cells) and the three protective measures (gross pathology, shedding, and viremia) at 14 dpc. While numbers in italics represent non-significant correlations, the bold numbers emphasize significant correlations (p < 0.05).