TABLE 2.
Pregnancy, birth, and infant outcomes among pregnancies with SARS‐CoV‐2 infection during by trimester of infection, SET‐NET, 22 Jurisdictions, January 25, 2020–December 31, 2020
| Total n (%) a | First or second trimester infection n (%) b | Third trimester infection n (%) a | Adjusted prevalence ratio c (95% CI) d | |
|---|---|---|---|---|
| Total | 35,767 | 17,615 (49.2) | 18,152 (50.8) | |
| Days from first positive PCR test to pregnancy outcome (median, IQR Q1‐Q3) | 71 (12–147) | 149 (108–199) | 13 (1–43) | |
| Pregnancy outcome e | 35,767 | 17,615 | 18,152 | |
| Live birth | 35,574 (99.5) | 17,470 (99.2) | 18,104 (99.7) | |
| Pregnancy loss | 193 (0.5) | 145 (0.8) | 48 (0.3) | |
| <20 weeks gestation | 52 (0.1) | 52 (0.3) | n/a | |
| ≥20 weeks gestation (stillbirth) | 141 (0.4) | 93 (0.5) | 48 (0.3) | 0.59 (0.34–1.03) |
| NICU admission f , g | 32,319 | 16,200 | 16,119 | |
| Yes | 3,529 (10.9) | 1,655 (10.2) | 1874 (11.6) | 1.13 (1.06–1.21) d |
| Term (≥37 weeks) | 1821 (5.6) | 735 (4.5) | 1,086 (6.7) | 1.29 (1.16–1.36) c |
| Preterm (<37 weeks) | 1708 (5.3) | 920 (5.7) | 788 (4.9) | |
| No | 28,790 (89.1) | 14,545 (89.8) | 14,245 (88.4) | |
| Small for gestational age f | 34,522 | 17,101 | 17,421 | |
| Yes | 1844 (5.3) | 827 (4.8) | 1,017 (5.8) | 1.16 (1.06–1.27) d |
| No | 32,678 (94.7) | 16,274 (95.2) | 16,404 (94.2) | |
| Gestational age h | 27,430 | 17,459 | 9,971 | |
| Term (≥37 weeks) | 23,598 (86.0) | 15,398 (88.2) | 8,200 (82.2) | |
| Preterm (<37 weeks) | 3,832 (14.0) | 2061 (11.8) | 1771 (17.8) | 1.44 (1.35–1.54) d |
| Late preterm (34–37 weeks) | 2,825 (10.3) | 1,410 (8.1) | 1,415 (14.2) | |
| Moderately preterm (28 to <34 weeks) | 831 (3.0) | 475 (2.7) | 356 (3.6) | |
| Very preterm (<28 weeks) | 176 (0.6) | 176 (1.0) | n/a | |
| Unknown | 11 (0.0) | 11 (0.1) | 0 (0.0) |
Abbreviations: CI, confidence interval; IQR, interquartile range.
Participating jurisdictions included Arkansas, City of Chicago, Georgia, City of Houston, Iowa, Illinois (excluding Chicago), Massachusetts, Maryland, Michigan, Minnesota, Missouri, Nebraska, New Hampshire, New Jersey, New York (excluding New York City), Pennsylvania (excluding Philadelphia), Philadelphia County, Puerto Rico, South Carolina, Tennessee, U.S. Virgin Islands, and Washington.
Trimester of SARS‐CoV‐2 infection is based on calculated date of last menstrual period and date of first positive COVID‐19 laboratory result.
Covariates include maternal age, race/ethnicity, and health insurance. For trimester of infection analyses, the reference group is first or second trimester infection.
95% confidence interval excluded 1.0 indicating an association that is statistically significant at the 5% level.
Other pregnancy outcomes (e.g., terminations and nonlive births) were reclassified as pregnancy losses based on gestational age of outcome provided. Pregnancy outcomes include multiple gestations.
Among Live births.
Reason for admission may be for infection control and prevention purposes.
Among those with infection occurring <37 weeks gestation (i.e., could have had a preterm birth), restricted to live births with known gestational age.