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. 2023 Jan 12;22(12):3188–3189. doi: 10.1111/ajt.17166

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Copyright © 2022 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.

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Protocol allograft kidney biopsies on month 3 and month 12. (A–C) Month 3 allograft kidney biopsy showing normal glomeruli on Masson Trichrome staining (A, × 200), negative C4d on peritubular capillaries and glomerular basement membrane (B, x 200) by immunohistochemistry, and negative PLA2R on glomerular basement membrane by immunohistochemistry (C, × 200). (D–F) Month 12 allograft kidney biopsy showing normal glomeruli on Masson Trichrome staining (D, × 200) but C4d immunohistochemistry revealed positive granular deposits along the glomerular basement membrane consistent with membranous nephropathy. Anti-PLA2R immunohistochemistry showed a positive staining of the extramembranous deposits. [Color figure can be viewed at wileyonlinelibrary.com]