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Proposed reaction mechanism of halohydrin dehalogenase. (A) Reaction mechanism and active site residues of SDRs exemplified by 7α-hydroxysteroid dehydrogenase of E. coli (adapted from references 13 and 29). Interactions of the conserved lysine residue with the ribose moiety of the cofactor are not included. (B) Proposed reaction mechanism and active site residues of halohydrin dehalogenase exemplified by HheC of A. radiobacter (see text for explanation).
