TABLE 2.

Heterogeneity and pleiotropic analysis for epigenetic age and susceptibility and severity of COVID-19.

		Q-statistics		Pleiotropic test
Exposure	Outcome	MR Egger	IVW	egger_intercept	pval
severity	PhenoAge	Q = 3.732769 P = 0.15468194	Q = 6.295249 P = 0.09809672	0.1253222	0.3619954
severity	GrimAge	Q = 2.164249 P = 0.3388748	Q = 2.572849 P = 0.4622694	0.03953384	0.6014878
severity	Hannum	Q = 5.522722 P = 6.769419	Q = 6.769419 P = 0.07962183	0.06785559	0.5708542
severity	HorvathAge	Q = 5.999045 P = 0.04981084	Q = 8.551572 P = 0.03588715	−0.1001956	0.453661
susceptibility	PhenoAge	Q = 11.42739 P = 0.02215828	Q = 14.92942 P = 0.01066820	−0.126466	0.3303144
susceptibility	GrimAge	Q = 4.090812 P = 0.3938553	Q = 4.147770 P = 0.5283430	−0.01238793	0.825028
susceptibility	Hannum	Q = 3.541134 P = 0.4716515	Q = 4.114188 P = 0.5330956	−0.03829989	0.4911899
susceptibility	HorvathAge	Q = 1.118961 P = 0.8912523	Q = 1.798353 P = 0.8762834	−0.04313577	0.456077
PhenoAge	severity	Q = 5.498383 P = 0.06397958	Q = 5.540632 P = 0.13622847	0.0130317	0.9126766
PhenoAge	susceptibility	Q = 6.542816 P = 0.2569210	Q = 6.951553 P = 0.3253508	−0.01010271	0.6003429
GrimAge	severity	NA	Q = 0.1205111 P = 0.7284808	NA	NA
GrimAge	susceptibility	Q = 0.1546549 P = 0.9255867	Q = 15.8688032 P = 0.0012064	0.3218178	0.05814232
Hannum	severity	NA	NA	NA	NA
Hannum	susceptibility	Q = 0.1054338 P = 0.9911775	Q = 0.1103816 P = 0.9985319	−0.001418437	0.9483488
HorvathAge	severity	Q = 15.77730 P = 0.2613651	Q = 15.92194 P = 0.3181648	0.007999366	0.7354521
HorvathAge	susceptibility	Q = 18.18951 P = 0.4432353	Q = 18.18961 P = 0.5098077	−6.61E-05	0.9921911