Table 2.
Association between embryo morphological features and birth weight z-score.
| Variable | category | Fresh cleavage transfer | Fresh blastocyst transfer | Frozen blastocyst transfer | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| unadjusted | adjusted | unadjusted | adjusted | unadjusted | adjusted | ||||||||
| coefficient(95% CI) | p | coefficient(95% CI) | p | coefficient(95% CI) | p | coefficient(95% CI) | p | coefficient(95% CI) | p | coefficient(95% CI) | p | ||
| Early cleavage | yes | -0.01 (-0.14 to 0.13) | 0.91 | -0.01 (-0.14 to 0.12) | 0.91 | 0.12 (-0.05 to 0.29) | 0.16 | 0.11 (-0.07 to 0.28) | 0.23 | 0.04 (-0.05 to 0.13) | 0.38 | 0.05 (-0.04 to 0.14) | 0.30 |
| no | Ref | – | Ref | – | Ref | – | Ref | – | Ref | – | Ref | – | |
| Day-3 Fragmentation | ≥10% | 0.33 (0.09 to 0.56) | 0.01 | 0.27 (0.03 to 0.5) | 0.02 | 0.35 (0.04 to 0.66) | 0.03 | 0.42 (0.11 to 0.74) | 0.01 | 0.04 (-0.1 to 0.17) | 0.61 | 0.02 (-0.12 to 0.16) | 0.74 |
| <10% | Ref | – | Ref | – | Ref | – | Ref | – | Ref | – | Ref | – | |
| Cell number | >8 cells | 0.18 (-0.03 to 0.38) | 0.10 | 0.15 (-0.06 to 0.36) | 0.16 | 0 (-0.19 to 0.19) | 0.99 | -0.04 (-0.23 to 0.16) | 0.71 | 0.09 (-0.02 to 0.19) | 0.10 | 0.06 (-0.05 to 0.16) | 0.27 |
| <8 cells | 0.08 (-0.11 to 0.27) | 0.40 | -0.05 (-0.25 to 0.15) | 0.599 | 0.04 (-0.2 to 0.28) | 0.744 | 0.12 (-0.12 to 0.36) | 0.324 | 0.11 (0 to 0.21) | 0.054 | 0.08 (-0.03 to 0.19) | 0.162 | |
| 8 cells | Ref | – | Ref | – | Ref | – | Ref | – | Ref | – | Ref | – | |
| Symmetry | uneven | -0.01 (-0.18 to 0.17) | 0.95 | -0.09 (-0.27 to 0.09) | 0.33 | 0.02 (-0.19 to 0.23) | 0.84 | 0.04 (-0.18 to 0.26) | 0.71 | 0.09 (-0.01 to 0.19) | 0.08 | 0.09 (-0.01 to 0.19) | 0.09 |
| even | Ref | – | Ref | – | Ref | – | Ref | – | Ref | – | Ref | – | |
| Cleavage score | Grade I | -0.15 (-0.44 to 0.15) | 0.32 | 0 (-0.3 to 0.3) | 0.99 | -0.13 (-0.56 to 0.29) | 0.54 | -0.12 (-0.54 to 0.3) | 0.59 | -0.17 (-0.41 to 0.07) | 0.17 | -0.12 (-0.36 to 0.12) | 0.33 |
| Grade II | -0.08 (-0.31 to 0.15) | 0.47 | 0.05 (-0.18 to 0.27) | 0.70 | -0.17 (-0.4 to 0.07) | 0.16 | -0.14 (-0.37 to 0.09) | 0.24 | -0.09 (-0.19 to 0.02) | 0.11 | -0.08 (-0.18 to 0.03) | 0.14 | |
| Grade III | Ref | – | Ref | – | Ref | – | Ref | – | Ref | – | Ref | – | |
| ICM | C | – | – | – | – | 0.25 (-0.38 to 0.89) | 0.43 | 0.16 (-0.49 to 0.81) | 0.63 | 0.23 (-0.11 to 0.56) | 0.18 | 0.18 (-0.16 to 0.51) | 0.31 |
| B | – | – | – | – | -0.07 (-0.28 to 0.13) | 0.48 | -0.1 (-0.33 to 0.13) | 0.39 | 0.06 (-0.05 to 0.16) | 0.28 | 0.05 (-0.06 to 0.16) | 0.34 | |
| A | – | – | – | – | Ref | – | Ref | – | Ref | – | Ref | – | |
| TE | C | – | – | – | – | 0.1 (-0.44 to 0.64) | 0.71 | 0.01 (-0.54 to 0.57) | 0.96 | 0.17 (-0.08 to 0.42) | 0.19 | 0.05 (-0.2 to 0.3) | 0.69 |
| B | – | – | – | – | -0.07 (-0.23 to 0.09) | 0.37 | -0.03 (-0.2 to 0.13) | 0.72 | -0.02 (-0.11 to 0.07) | 0.65 | -0.05 (-0.15 to 0.04) | 0.27 | |
| A | – | – | – | – | Ref | – | Ref | – | Ref | – | Ref | – | |
| Blastocyst score | Poor | – | – | – | – | 0.15 (-0.31 to 0.6) | 0.53 | 0.16 (-0.31 to 0.62) | 0.51 | 0.24 (0.02 to 0.46) | 0.03 | 0.17 (-0.06 to 0.39) | 0.14 |
| Fair | – | – | – | – | -0.11 (-0.36 to 0.14) | 0.36 | -0.09 (-0.36 to 0.17) | 0.49 | 0.05 (-0.08 to 0.17) | 0.45 | 0.03 (-0.1 to 0.16) | 0.64 | |
| Good | – | – | – | – | -0.04 (-0.3 to 0.22) | 0.77 | -0.03 (-0.29 to 0.24) | 0.85 | 0.11 (-0.03 to 0.24) | 0.12 | 0.08 (-0.05 to 0.21) | 0.23 | |
| Top | – | – | – | – | Ref | – | Ref | – | Ref | – | Ref | – | |
Models were adjusted for maternal age, BMI, parity, peak estradiol level, endometrial thickness, insemination protocol (IVF or ICSI), female etiologies (tubal factor, endometriosis), order of transfer (1 or >1), mode of delivery (vaginal or Cesarean), and year of treatment. CI, confidence interval; ICM, inner cell mass; TE, trophectoderm.
The bold values indicate significant at P<0.05.