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. 2022 Sep 23;13:951133. doi: 10.3389/fendo.2022.951133

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Copyright © 2022 Wang, Mao, Liu and Duan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Appearance of the patient, adrenal CT, postoperative gross, HE and histochemical staining. (A) Appearance and lower abdomen purple streaks; (B, C) Lip mucosa and multiple skin spot-like pigmentation; (D) Posterior neck skin myxoma; (E) Adrenal CT: bilateral adrenal nodules, the left side diameter is 1.9 cm, the enhanced CT value is approximately 40 HU; (F, G) Postoperative gross after left adrenalectomy: The diseased tissue is grayish-yellow–gray–brown, 4.5•2.5•2 cm, multinodular, some cells have pigmentation, and the surrounding cortex is squeezed and thinned; (H) After hematoxylin-eosin staining, brown are seen particles •400; (I–L) Immunohistochemistry of SYN (•200), Inhibin-α (•200), CYP11B1and CYP11B2 (•400). CT, Computed tomography; HE, hematoxylin-eosin.