TABLE 1.
Baseline characteristics by the genetic risk categories (one dose)
| Overall | High PRS groups | |||
|---|---|---|---|---|
| Top 33% | Top 20% | Top 5% | ||
| Number | 359 310 | 119 770 | 71 862 | 17 965 |
| Demographics | ||||
| Age, mean (SD) | 69.05 (8.04) | 69.10 (8.01) | 69.14 (8.02) | 69.11 (8.02) |
| Sex, male (%) | 160 327 (44.6) | 53 178 (44.4) | 31 766 (44.2) | 7909 (44.0) |
| BMI, mean (SD) | 27.30 (4.69) | 27.29 (4.69) | 27.29 (4.69) | 27.26 (4.69) |
| Socioeconomic status, mean (SD) | ||||
| Indices of multiple deprivation | 17.18 (13.62) | 17.00 (13.50) | 16.91 (13.43) | 16.71 (13.27) |
| Income score | 0.11 (0.09) | 0.11 (0.09) | 0.11 (0.09) | 0.11 (0.09) |
| Employment score | 0.09 (0.06) | 0.09 (0.06) | 0.09 (0.06) | 0.08 (0.06) |
| Health score | −0.11 (0.84) | −0.12 (0.84) | −0.13 (0.84) | −0.14 (0.84) |
| Education score | 15.23 (15.84) | 15.14 (15.75) | 15.09 (15.74) | 14.98 (15.70) |
| Housing score | 19.76 (10.12) | 19.64 (10.08) | 19.58 (10.07) | 19.47 (10.10) |
| Crime score | −0.06 (0.77) | −0.06 (0.77) | −0.07 (0.77) | −0.07 (0.78) |
| Living environmental score | 18.28 (15.07) | 18.15 (14.96) | 18.08 (14.89) | 17.93 (14.66) |
Note: Indices of multiple deprivation offer a more complex and detailed view of deprivation, based on more factors than the Townsend index. All scores have been scaled to 0–1, 0–100, or even distributions standardized around 0, with higher values indicating more deprived. Details of individual score has been described in the GOV.UK (https://www.gov.uk/government/collections/english‐indices‐of‐deprivation).