Figure 4.

Viral polyprotein cleavage sites recognized by PL^pro. Represented are the recognition motifs of SARS‐CoV‐2, ^[19] SARS‐CoV‐1, ^[21] and MERS‐CoV, ^[23] covering residues P₅–P₅′ (Schechter‐Berger nomenclature) ^[45] within pp1a and pp1ab. Note that the recognized polyprotein sequences of SARS‐CoV‐2, ^[19] BANAL‐52, ^[20a] and RaTG13 ^[20b] are identical from P₅–P₅′ (Table 1). The consensus sequence over the three cleavage sites (nsp1↓nsp2, nsp2↓nsp3, nsp3↓nsp4) was plotted using WebLogo 3. ^[47]