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. 2022 Sep 21:10.1002/jmv.28138. Online ahead of print. doi: 10.1002/jmv.28138

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© 2022 Wiley Periodicals LLC.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Spike mutations affect the biological behavior of five SARS‐CoV‐2 Omicron lineages. Blue, BA.1 has an additional six amino acid deletions, three insertions, and nine substitutions compared to BA.2; Red, BA.1.1 contains unique mutation R346K compared to BA.1; Green, BA.2 has eight specific mutations compared to BA.1, BA.1.1, BA.3, BA.4, and BA.5; Purple, BA.2.12.1 contains unique mutation L452Q + S704F compared to BA.2; Yellow, BA.4 and BA.5 have specific del69‐70, L452R, F486V, R493Q compared with BA.2; Black, all Omicron lineage have 20 identical spike mutations.